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HPMC Capsules vs. Gelatin Capsules: Which One is Better?

HPMC Capsules vs. Gelatin Capsules: Which One is Better?

  • Categories:Industry News
  • Author:Maggie
  • Origin:Humanwell
  • Time of issue:2025-01-03 14:19
  • Views:

(Summary description)As a common drug carrier, capsules have been widely used in the market of medicines, health products and nutritional supplements. The main components of empty capsules are gelatin and hydroxypropyl methylcellulose (HPMC). So, what are the differences between gelatin capsules and HPMC capsules? and which one is better? Let's talk about it.

HPMC Capsules vs. Gelatin Capsules: Which One is Better?

(Summary description)As a common drug carrier, capsules have been widely used in the market of medicines, health products and nutritional supplements. The main components of empty capsules are gelatin and hydroxypropyl methylcellulose (HPMC). So, what are the differences between gelatin capsules and HPMC capsules? and which one is better? Let's talk about it.

  • Categories:Industry News
  • Author:Maggie
  • Origin:Humanwell
  • Time of issue:2025-01-03 14:19
  • Views:
Information

As a common drug carrier, capsules have been widely used in the market of medicines, health products and nutritional supplements. The main components of empty capsules are gelatin and hydroxypropyl methylcellulose (HPMC). So, what are the differences between gelatin capsules and HPMC capsules? and which one is better? Let's talk about it.


What Are HPMC Capsules and Its Features?
HPMC capsules, whose full name is Hydroxypropyl Methylcellulose capsules, are capsules made from hydroxypropyl methylcellulose that are used to encapsulate drugs and other nutritional supplements. Hydroxypropyl methylcellulose is a semi-synthetic cellulose derivative that has many uses, especially as excipients in the pharmaceutical industry. Here are some of the features of HPMC capsules:
Plant-derived: HPMC capsules are derived from plants and are suitable for vegetarians and consumers with contraindications to animal-derived ingredients.
Stability: HPMC capsules have high chemical and physical stability under a variety of environmental conditions and are not susceptible to humidity.
Solubility: Empty HPMC capsules dissolve well in the body and release drugs.
Odorless: Similar to gelatin capsules, HPMC capsules are usually odorless and do not affect the taste of the drug.


What Are Gelatin Capsules and Its Features?
Gelatin capsules, a common form of drug encapsulation, are made primarily of gelatin, a protein derived from animal skin, bone, and connective tissue. Here are some of the characteristics of gelatin capsules:
Solubility: Gelatin capsules can quickly dissolve under the action of human stomach acid, releasing the drug inside the capsule.
Odorless: gelatin itself is odorless and will not affect the taste of the drug.
Biocompatibility: gelatin has good biocompatibility and is harmless to the human body.
Fillability: Various forms of medicine can be filled, including powder, small particles or liquid.

 

HPMC Capsules vs. Gelatin Capsules: Which One is Better?

Firstly, we analyze the composition. The main ingredient in gelatin capsules is gelatin, a natural protein derived from animal skin, bone, and connective tissue. The main HPMC capsule ingredients is hydroxypropyl methylcellulose, which is a synthetic polymer derived from natural cellulose.

Secondly, in terms of solubility, there are differences. Gelatin capsules dissolve easily in the stomach acid environment, releasing drugs, but they are prone to cracking in low temperatures or humid environments. The solubility of HPMC capsule is not affected by temperature and humidity, and has better stability.

And then there's adaptability. Gelatin capsules are suitable for gastrolytic drugs, that is, drugs that dissolve in an acidic environment in the stomach. HPMC capsules are suitable for enteric drugs, that is, drugs that dissolve in the intestinal environment. This means that HPMC capsules can protect the drug from gastric acid damage as it passes through the stomach, making it work best in the gut.

In addition, among vegetarians and religious people, HPMC capsules are more advantageous. Since gelatin comes from animals, it may not be acceptable to this segment of the population. HPMC capsules are derived from plants and meet the needs of vegetarians and some religious believers.

In terms of storage conditions, gelatin capsules and HPMC capsules are also different. Gelatin capsules need to be stored in a dry, cool environment to prevent moisture and spoilage. HPMC capsule has relatively low requirements for storage environment and strong adaptability.

Finally, let's look at environmental issues. Because HPMC capsules are derived from plants, they have less impact on the environment during production than gelatin capsules. In the context of global advocacy of green environmental protection, HPMC capsules have a broader market prospect.

In short, there are some differences between gelatin capsules and HPMC capsules in terms of composition, solubility, adaptability, storage conditions and environmental protection. When consumers choose capsule products, they can choose the right products according to their needs and actual conditions. At the same time, with the development of science and technology, there may be more new capsule materials in the future, bringing more possibilities to the market of pharmaceuticals, health products and nutritional supplements.

About HumanwellCaps
Hubei Humanwell Pharmaceutical Excipients Co., Ltd.is a high-tech branch of Humanwell Healthcare Group, specializing in the production of capsules, and with over 20 years of capsules production experience. It is with planned total annual production capacity of 40 billions of empty capsules, currently has 16 imported automatic capsule production lines, and with an annual production capacity of 15 billions of capsules. 

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